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Protein Labeling Market Overview
The Protein Labeling Market size is estimated to reach $3.4 billion by 2027, growing at a CAGR of 8.4% during the forecast period 2022-2027. Protein labeling indicates the utilization of suitable molecular labels to discover or purify the labeled protein and its binding partners. Protein labeling applies a short tag to lessen the disruption of protein folding and function. Biotinylation, also termed as biotin tagging/labeling, is the technique of affixing biotin to a protein molecule and added macromolecules. The technique of photoaffinity labeling allows the direct investigation of target protein by way of a covalent bond established between a ligand and its particular receptor. The photoaffinity labeling, therefore, is implemented in two phases of drug discovery and development procedures. Labeling approaches lead to the covalent adherence of distinct molecules, inclusive of biotin, reporter enzymes, fluorophores and radioactive isotopes, to the target protein or nucleotide sequence. Radioactive labeling most typically involves proteins being radioactively labeled with 35S owing to the reduced-energy beta emissions being comparatively safe to cells, yet effortlessly discernible. Enzymatic labeling is a technique utilized in bioanalysis in which chemical markers are arranged on molecules inside a material. Enzymatic labeling is a significant approach in protein labeling. The increasing count of novel product launches and amplifying acceptance of bioengineering technologies in conjunction with labeling approaches like enzymatic labeling are propelling the growth of the Protein Labeling Market. The burgeoning technological progress and the boost in spend on R&D resulting in the decrease of complication in procedures for protein labelling by firms in conjunction with enhancement in current technologies are set to propel the growth of the Protein Labeling Market during the forecast period 2022-2027. This represents the Protein Labeling Industry Outlook.
Report Coverage
The report: “Protein Labeling
Market Forecast (2022-2027)”, by Industry ARC, covers an in-depth
analysis of the following segments of the Protein Labeling Market.
By
Product: Reagents & Kits, Services, Others.
By Labeling Method: In-Vitro Labeling, In-vivo Labeling, Bioorthogonal
Labeling.
By
Application: Immunological Techniques,
Cell-Based Assays, Fluorescence Microscopy, Protein Microarrays, Mass
Spectroscopy.
By Geography: North America (the U.S,
Canada and Mexico), Europe (UK, Germany, France, Italy, Spain, Russia and Rest
of Europe), Asia-Pacific (China, India, Japan, South Korea, Australia & New
Zealand, and Rest of Asia-Pacific), South America (Brazil, Argentina, Rest of
South America) and Rest Of The World (Middle East, Africa).
Key Takeaways
- Geographically, North America Protein Labeling Market accounted for the highest revenue share in 2021 and it is poised to dominate the market over the period 2022-2027 owing to the strongly established and methodical healthcare industry with protein labeling techniques like biotin labeling and the soaring inspiration for research and development in the North American region.
- Protein Labeling Market growth is being driven by the heightening research on the protein binding mechanism by way of specially-designed fields of studies, like proteomics and protein chemistry and the increased application of protein labelling techniques like enzymatic labelling and radioactive labeling. However, the rising competition in the Protein Labeling Market and the dearth of skilled professionals are the major factors hampering the growth of Protein Labeling Market.
- Protein Labeling Market Detailed Analysis on the Strength, Weakness, and Opportunities of the prominent players operating in the market will be provided in the Protein Labeling Market report.
Protein Labeling Market Share, By Application, 2021(%)
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Protein Labeling Market Segment Analysis – By Product:
The Protein Labeling Market
based on product can be further segmented into Reagents & Kits, Services and Others. The Reagents & Kits Segment held the largest market share in 2021.
This growth is owing to the increase in the count of labeling agents and
genetically engineered labels being detected. Biotin peg linkers (reagents) are
convenient biotinylation reagents in nonradioactive purification, discovery,
immobilization, labeling and targeting. The increased commercial accessibility
of effective reagents like the Invitrogen No-Stain Protein Labeling Reagent offering
a malleable, precise, accelerated and trustworthy technique to envision and
normalize proteins in a gel or on a membrane (post-transfer) is further
fuelling the growth of this segment.
Furthermore, the Services segment is estimated to grow with the fastest
CAGR of 9.1% during the forecast period 2022-2027 owing to the increased applications
of protein labeling techniques like biotin labeling, enzymatic labeling and
fluorescent labeling.
Protein Labeling Market Segment Analysis – By Application:
The Protein Labeling
Market based on application can be further segmented into Immunological Techniques, Cell-Based Assays, Fluorescence Microscopy,
Protein Microarrays and Mass Spectroscopy. The Fluorescence Microscopy Segment held the largest market
share in 2021. This growth is owing to the
increased application of fluorescent tagging
or labeling, utilizing a reactive derivative of a fluorescent molecule termed fluorophore.
Protein labeling includes the application of labeling techniques like enzymatic
labeling and radioactive labeling. The extensive application of fluorescent
proteins in immunochemistry, fluorescence in situ hybridization (FISH), cell
tracing, receptor labelling and fluorescence spectroscopy is further propelling
the growth of this segment.
Furthermore, the Mass Spectroscopy segment is estimated to grow with the fastest CAGR of 9.3% during the forecast period 2022-2027 owing to the benefits of mass spectroscopy like it being a very quick, accurate and sensitive technique and its ability to recognize unknown constituents in a sample solution. Owing to the great compatibility of biotin for avidin, proximity labelling can capture weak/transient protein communications and be utilized for both soluble and insoluble proteins, which can be demanding for typical antibody-based affinity purification/mass spectrometry techniques. The capability of mass spectroscopy to integrate with added procedures like high-performance liquid chromatography (LC-MS) and gas chromatography (GC-MS) is further propelling the growth of this segment.
Protein Labeling Market Segment Analysis – By Geography:
The Protein Labeling
Market based on geography can be further segmented into North America, Europe,
Asia-Pacific, South America and Rest of the World. North America (Protein
Labeling Market) held the largest share with 36% of the overall market in 2021.
The growth of this region is owing to the soaring growth of protein labelling involving
techniques like radioactive labeling as a sector of research owing to the
extensive collection of applications in the North American region. The
existence of supportive policies backing this kind of research, the surging
acceptance in personalized medicine and genomic sequencing are further
propelling the growth of protein labeling market in the North American region.
Furthermore, the Asia-Pacific region is estimated to be the region with the fastest CAGR rate over the forecast period 2022-2027. This growth is owing to factors like development of healthcare infrastructure and boost in spend on R&D. The increasing predominance of incessant ailments like cancer and the flourishing pharmaceutical sector with protein labelling techniques like enzymatic labeling are further fuelling the progress of the Protein Labeling Market in the Asia-Pacific region.
Protein Labeling Market Drivers
Mass Spectrometry Is Expediting Quantitative Proteomics Which Is Projected To Drive The Growth Of Protein Labeling Market:
Protein Labeling involves techniques like radioactive labeling and enzymatic labeling. Mass spectrometry (MS) has evolved from being utilized mostly in habitual analytical functions to developing into an effective biological technique for protein quantitation. Protein scrutiny utilizing Mass Spectrometry influences its high-resolution accurate mass measurements in conjunction with an extensive database to recognize and assess different proteins in a sample. To completely understand the pathophysiology of ailments, researchers require a profound comprehension of the proteins included, their expression levels and how they communicate with one another. As projects scale-up in size and need more recreate able and precise techniques, biologists can augment the promising possibility of their research by adding Mass Spectrometry in their ventures. This is fuelling the growth of the Protein Labeling Market during the forecast period 2022-2027.
Technological Innovations Are Expected To Boost The Demand Of Protein Labeling:
Besides the kinds of protein labelling like radioactive labeling, technological innovations are driving the growth of the Protein Labeling market. New England Biolabs has launched a series of protein tools for the particular labeling of fusion proteins with synthetic probes that will assist scientists in highlighting different facets of protein function. New England Biolabs (NEB) has established a series of new tagging technologies for particularly labeling fusion proteins in cell biology and protein science applications. The most flexible of these tags is the SNAP-tag, a 20 kDa mutant of the DNA repair protein O6-alkylguanine-DNA alkyltransferase that reacts particularly and expeditiously with benzylguanine (BG) derivatives, resulting in irrevocable covalent labeling of the SNAP-tag with a synthetic probe. SNAP-tag has numerous characteristics that make it perfect for different applications in protein labeling. The second tag launched by NEB is kin of the SNAP-tag, the CLIP-tag. The CLIP-tag was developed by engineering the substrate specificity of the SNAP-tag, allowing it to react particularly with O2-benzylcytosine (BC) derivatives. The principal use of the CLIP-tag is dual-labeling of fusion proteins together with the SNAP-tag. A third technique provided by NEB is notionally distinct from the labeling of SNAP and CLIP fusion proteins as it is established on an enzyme-catalyzed post-translational alteration. The protein of interest is fused to an acyl carrier protein (ACP) and the reciprocal fusion protein is particularly labeled with CoA derivatives by way of a post-translational alteration catalyzed by the phosphopantetheinyl transferase AcpS. In addition, a mutant of ACP, termed MCP, is labeled by the phosphopantetheinyl transferase Sfp but not by AcpS, thereby allowing the discriminatory labeling of ACP and MCP fusion proteins with distinct probes in one sample. These kinds of technological innovations are driving the growth of the Protein Labeling Market during the forecast period 2022-2027.
Protein Labeling Market Challenges
Limitations Of Conventional Iodinated Reagents Are Hampering The Growth Of Protein Labeling Market:
Though conventional iodinated reagents have been utilized profitably to acquire data on protein interactions, they have some basic inadequacies in comparison with trifunctional reagents constructed for label transfer applications. Conventional Iodinated Reagents need labeling with I-125 prior to application, and the effectiveness of label inclusion is less. The photoactivation step may lead to various fruitless pathways that lessen the crosslinking output between inducement and target of attack. The I-125 label can be freed at the time of the light reaction, bringing about nonspecific labeling of the protein(s) in the blend. Some molecules have deficiency of suitable groups that can be iodinated, and therefore may need alteration at primary amines utilizing Bolton-Hunter Reagent. More novel types of compounds have been established as trifunctional reagents that more sufficiently discriminate and separate the reactive sites from the label. More and more of these novel types of reagents are inclusive of non-radioisotopic labels like biotin. The limitations of conventional iodinated reagents hamper the growth of the Protein Labeling Market.
Protein Labeling Market Landscape:
Product launches, mergers & acquisitions, joint ventures and R&D activities are key strategies adopted by players in the Protein Labeling Market. Key companies of this market include:
- GE Healthcare
- Thermo Fisher Scientific Inc
- Merck KGaA
- Perkinelmer Inc
- LI-COR Biosciences
- F. Hoffmann-La Roche AG
- New England Biolabs
- Biotium
- Abcam
- ZEDIRA GmbH
Acquisitions/Product Launches:
- In September 2020, GE Healthcare launched its Thoracic Care Suite, an assortment of eight artificial intelligence (AI) algorithms from Lunit Insight CXR to assist in the relief of clinical strain owing to COVID-19.
- As SARS-CoV-2 research endeavors persist worldwide, laboratories are handling more and more scientific investigations utilizing banked saliva samples, imposing on a sample type which is effortless to access and non-intrusive. Towards this objective, Thermo Fisher Scientific has introduced the Thermo Scientific SpeciMAX Stabilized Saliva Collection Kit in September 2021, which is planned to securely accumulate saliva for research.
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