Tangential Flow Filtration Market - Forecast(2024 - 2030)

Tangential Flow Filtration Market size is estimated to reach $1.9 billion by 2027, growing at a CAGR of 12.1% during the forecast period 2022-2027. Tangential flow filtration (TFF), also termed Cross-flow filtration, is a technique of segregation extensively utilized in bio-pharmaceutical and food industries. Tangential flow filtration (TFF) is distinct from other filtration systems in which the liquid is moved onward parallel to the filter, instead of being thrust by way of a membrane perpendicularly which can congest the filter media. Conventionally, membrane filters have been performed by establishing a porous membrane perpendicularly across the path of a liquid mixture from which a chosen species is to be filtered. The fluid mixture runs by way of the membrane and the chosen species is detained by the membrane. Amid bacteria-size membranes, polyvinylidene difluoride (PVDF) membranes have demonstrated greater bacterial restoration, however lesser viral permeation effectiveness than polyethersulfone (PES) membranes, irrespective of surroundings and scales of TFF. Reverse Osmosis (RO) and Nanofiltration (NF) are kinds of TFF where very compact membranes are utilized to segregate salts and tiny molecules with molecular masses commonly lesser than 1500 Daltons from water or other solvents. Microfiltration (MF) is commonly utilized upstream in a restoration technique to segregate unbroken cells and a few cell debris/lysates from the remainder of the constituents in the feed stream. The benefits of Tangential Flow Filtration over normal flow filtration are set to drive the Tangential Flow Filtration Market. The boost in the acceptance of single-use technologies like microfiltration is set to propel the growth of the Tangential Flow Filtration Market during the forecast period 2022-2027. This represents the Tangential Flow Filtration Industry Outlook. 

Key Takeaways

• Geographically, North America Tangential Flow Filtration Market accounted for the highest revenue share in 2021 and it is poised to dominate the market over the period 2022-2027 owing to the existence of leading players like Danaher and big pharmaceutical and biopharmaceutical industries employing tangential flow filtration techniques like reverse osmosis in the North American region.
• Tangential Flow Filtration Market growth is being driven by the proliferating development in the biopharmaceutical sector utilizing tangential flow filtration methods like reverse osmosis and the increasing financing by pharmaceutical firms. However, the great capital spend needed to install novel manufacturing facilities is one of the major factors hampering the growth of the Tangential Flow Filtration Market.
• Tangential Flow Filtration Market Detailed Analysis on the Strength, Weakness, and Opportunities of the prominent players operating in the market will be provided in the Tangential Flow Filtration Market report. 

Tangential Flow Filtration Market Segment Analysis – By Product:

The Tangential Flow Filtration Market based on the product can be further segmented into Single-use Tangential Flow Filtration Systems, Reusable Tangential Flow Filtration Systems, Membrane Filters, and Filtration Accessories. The Single-use Tangential Flow Filtration Systems Segment held the largest market share in 2021. This growth is owing to the increasing acceptance of single-use technologies attributed to their advantages like minimized cross-contamination, a boost in flexibility, and reduced process time together with increased application of techniques like microfiltration. The completely automated single-use systems with advantages like minimized validation, lesser capital costs, and reduced cleaning needs are further propelling the growth of this segment.

Furthermore, the Reusable Tangential Flow Filtration Systems segment is estimated to grow with the fastest CAGR of 12.9% during the forecast period 2022-2027 owing to its advantages like effortless utilization, accelerated application, and increased effectiveness in conjunction with the proliferating application of techniques like microfiltration.

Tangential Flow Filtration Market Segment Analysis – By Technology:

The Tangential Flow Filtration Market based on technology can be further segmented into Ultrafiltration, Microfiltration, Reverse Osmosis, and Nanofiltration. The Microfiltration Segment held the largest market share in 2021. This growth is owing to the increased application of microfiltration in tangential flow filtration in an extensive series of uses like concentration and desalting of protein, peptide, and oligonucleotide solutions. Tangential-flow microfiltration may be utilized to clarify hard-to-filter solutions like crude plant extracts, which rapidly bring about membrane fouling when utilizing conventional dead-end filtration techniques and this is further propelling the growth of this segment.

Furthermore, the Reverse Osmosis segment is estimated to grow with the fastest CAGR of 13.2% during the forecast period 2022-2027 owing to the surging application of reverse osmosis in the purification of water and its increased cost-effectiveness in comparison with conventional evaporation techniques.

Tangential Flow Filtration Market Segment Analysis – By Geography:

The Tangential Flow Filtration Market based on geography can be further segmented into North America, Europe, Asia-Pacific, South America, and the Rest of the World. North America (Tangential Flow Filtration Market) held the largest share with 35% of the overall market in 2021. The growth of this region is owing to the heightening investments for the acceptance of progressive technologies and the increased application of tangential flow filtration techniques like reverse osmosis in the North American region. The boost in financing in R&D of different elementary technologies for biopharmaceutical industries is further propelling the growth of Tangential Flow Filtration in the North American region.

Furthermore, the Asia-Pacific region is estimated to be the region with the fastest CAGR rate over the forecast period 2022-2027. This growth is owing to factors like the surging development of the pharmaceutical sector and the rising growth of biosimilars. The increasing count of innovative product launches and the heightening application of microfiltration are fuelling the progress of the Tangential Flow Filtration Market in the Asia-Pacific region.

Tangential Flow Filtration Market - Drivers

Increasing Utilization Of Tangential Flow Filtration Is Projected To Drive the Growth Of Tangential Flow Filtration Market:

Typical tangential flow filtration techniques include reverse osmosis and nanofiltration. Tangential flow filtration is utilized in concentration and diafiltration procedures. It raises the concentration of a solution by eliminating liquids while retaining the solute molecules. The segregation of tiny and big particles, leaving the tinier particles behind without modifying the complete concentration at the end by cleaning out the rest of the salt with another buffer happen in diafiltration. This technique can also minimize the concentration of a solution by cleaning out the rest of the salts with water. Particular usages of tangential flow filtration are inclusive of pre-filtration constituent Water For Injection (WFI) systems to eliminate endotoxins and restoration of bacterial cultures and viruses. The growing utilization of tangential flow filtration is therefore fuelling the growth of the Tangential Flow Filtration Market during the forecast period 2022-2027.

Technological Innovations Are Expected To Boost the Demand Of Tangential Flow Filtration:

Technological innovations are driving the growth of the Tangential Flow Filtration market. Microfiltration is an extensively utilized technique of tangential flow filtration. As per a report in May 2020, Oxford Biomedica (OXB) a chief gene and cell therapy firm that concentrates on Lentiviral Vector (LV) technology innovation, progressed a GMP LV cell culture production platform from a cell factory-based backing cell technique to a more expandable, serum-free suspension technique functioning in single-use bioreactors, expanded-up to 200 L in volume at the present time to attend to boost in LV supply demand. The TFDF ™ (Tangential Flow Depth Filtration) technology has been established by Repligen Corporation (Repligen) for the harvest of lentiviral vectors from cell culture supernatant from the bioreactor. The TFDF™ technology efficiently segregated cells and cell debris from vector particles. Harvest yields commonly were in excess of 90% with flux rates between 700–750 liters/m2/hour (LMH) at both 5 and 50 L scales. The tangential mode of TFDF™ was discovered to be adequately gentle on the cells to back multiple harvests, opening the potential of highly heightening LV vector manufacture in a perfusion mode. These kinds of technological advancements are driving the growth of the Tangential Flow Filtration during the forecast period 2022-2027.

Tangential Flow Filtration Market – Challenges

Limitations Of Tangential Flow Filtration Are Challenging The Growth Of The Tangential Flow Filtration Market:

The basic cost of equipment is high. Tangential flow filtrations are slower flow rates than diatomaceous earth filtration (DE) or sheets. Module substitution is very costly. Bentonite will fill up and stop membranes. There is lesser regulation over the process of filtration. Tinier units range between 150-350 gallons/hour. The commencement cost is about $25,000. It is hard to compare vendors. Bigger units scale up to 15,000 GPH. Multiple filters are scalable. The limitations like high initial cost are challenging tangential flow filtration and hampering the growth of the Tangential Flow Filtration Market.

Tangential Flow Filtration Market - Landscape:

Novel product launches, mergers and acquisitions, and partnerships are key strategies adopted by players in the Tangential Flow Filtration Market. Key companies of this market include:

1. GE Healthcare
2. Sartorius AG
3. Danaher
4. Novasep
5. Merck KgaA
6. Repligen Corporation
7. Arker Hannifin Corporation
8. Alfa Laval Corporate AB
9. Andritz AG
10. Cole-Parmer Instrument Company

Acquisitions/Product Launches:

• In October 2021, Novasep continued to advance and innovate in the growth and manufacture of pharmaceutical molecules and declared the introduction of a novel industrial-scale HPLC system that is quicker, more secure, and more fruitful than ever: Hipersep® Process M.
• In March 2020, Sartorius introduced BIOSTAT STR® Generation 3 with BIOBRAIN—making biopharmaceutical growth and manufacture quicker, simpler, and more secure. There is accelerated procedure growth and smooth expandability from ambr® to BIOSTAT STR®.

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