Histone Methyltransferases Market Growth Drivers:
- Rising Applications of SMYD3:
Histone Methyltransferases (HMT) are histone-modifying
enzymes that mobilize the transfer of one, two or three methyl groups to
lysine and arginine residues of histone proteins. Based on type, the Histone
Methyltransferases Market is segmented into EZ, SET1, SET2, SMYD, SUV39,
SUV4-20 and RIZ. The recognition of SMYD3 has been recorded and it is a gene
that is over-expressed in most colorectal carcinomas and hepatocellular
carcinomas. The establishment of SMYD3 into NIH3T3 cells improves cell development,
whereas genetic knockdown with small-interfering RNAs (siRNAs) in cancer cells led
to considerable growth suppression. SMYD3 produced a complex with RNA
polymerase II by way of interaction with the RNA helicase HELZ and
transactivated a set of genes that involved oncogenes, homeobox genes and genes
connected with cell-cycle regulation. The rising applications of SMYD3 are therefore
driving the growth of the Histone Methyltransferases Market.
- Inhibitory Impacts of SUV4-20 H1 Histone Methyltransferase:
EZ, SET1, SET2, SMYD, SUV39, SUV4-20 and RIZ are
recognized as principal families of Histone Methyltransferases. It has been
recognized that SUV4-20 histone methyltransferases, particularly SUV4-20 H1, serve
a significant role in the regulation of FXN expression and depict a novel
therapeutic target. It has been discovered that pharmacological inhibition of
the SUV4-20 methyltransferases by the tool compound A-196 raised the expression
of FXN by approximately 1.5-fold in the reporter cell line. The inhibitory
impacts of SUV4-20 H1 Histone Methyltransferase are therefore propelling the
growth of the Histone Methyltransferases Industry, thereby contributing to the
growth of the Histone Methyltransferases Industry Outlook.
Acquisition
In September 2021, Boehringer Ingelheim declared the acquisition of Abexxa Biologics Inc. The acquisition would permit Boehringer Ingelheim to access Abexxa’s expertise in targeting cancer-specific proteins. These proteins are situated within the cell, instead of those expressed on the cell membrane.
Histone
Methyltransferases Market: Competitive Landscape